How do questionnaire definitions of atopy status affect sample size calculations for asthma cohort studies in a population of Canadian children?
نویسندگان
چکیده
Background Skin prick tests (SPT) are the gold standard for determining atopy. In epidemiological studies of childhood allergy, questionnaire responses are often used to define atopy and predict sample size. Questionnaire-reported hayfever symptoms have shown 28-76% sensitivity and 21-94% specificity compared to SPT. We evaluated how questionnaire definitions of atopy affect sensitivity, specificity and sample size calculations in a population of Canadian children.
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